홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-Aminothiazole → HCID 18381673, 화합물

HRID 2268889
노트
인쇄 미리보기

반응식

HRID 2268889 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5]([CH2:14][C:15]2[C:20]([Cl:21])=[CH:19][N:18]=[CH:17][C:16]=2[Cl:22])=[N:4][N:3]=1.[NH2:23][C:24]1[S:25][CH:26]=[CH:27][N:28]=1.C(N(CC)CC)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Cl:22][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([Cl:21])[C:15]=1[CH2:14][C:5]1[C:6]2[C:11](=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=2)[C:2]([NH:23][C:24]2[S:25][CH:26]=[CH:27][N:28]=2)=[N:3][N:4]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 21552-AminothiazoleHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 186292104-Chloro-1-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxyphthalazine

생성물 1

HCID 18381673HCID 18381673, 화합물수율 50%

시약·촉매·용매 1

HCID 167845
palladium(II) acetate
촉매

실험 절차

At 100° C. a solution of 4-chloro-1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazine (0.5 g, 1.41 mmoles), prepared as described in example 45, 2-aminothiazole (0.424 g, 4.23 mmoles), triethylamine (0.59 ml, 4.23 mmoles), palladium acetate (16 mg, 0.07 mmoles) and triphenylphosphine (56 mg, 0.21 mmoles) was stirred under N2. After 20 hours the mixture was poured into water/ice and extracted more times with CH2Cl2. The organic phase was washed with water, anhydrified and concentrated to give a solid which was flash chromatographed (eluent: hexane/ethyl acetate 7:3) yielding 0.24 g of the title compound (yield: 50%). m.p.: 218-220° C.

후처리

  1. extractionextracted more times with CH2Cl2
  2. washThe organic phase was washed with water, anhydrified
  3. concentrationconcentrated
  4. customto give a solid which
  5. customchromatographed (eluent: hexane/ethyl acetate 7:3)

출처 및 근거

ORD 기록
ord-35dd7773e7d34d8dbe275a90c741c77a
출처 데이터셋
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06329370B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트