Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine

HRID 2269438노트

반응식

HRID 2269438 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])=O)[CH:6]=[CH:7][CH:8]=1.Cl.[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH2:33])[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH:33][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])[C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 183471131-(3,4-Difluorophenyl)ethan-1-amine hydrochlorideHCID 701892132-Methoxy-5-nitrophenyl 3-methoxyphenyl ketone

생성물 1

HCID 18334104N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine수율 92.8%

시약·촉매·용매 2

HCID 24193Titanium Tetrachloride촉매HCID 176Acetic Acid용매

실험 절차

Following a similar procedure to that described in Example (1a), 600 mg of 2-methoxy-5-nitrophenyl 3-methoxyphenyl ketone, 809 mg of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 1.75 ml of triethylamine, 0.28 ml of titanium tetrachloride, 583 mg of sodium cyanoborohydride and 0.18 ml of acetic acid were reacted, to obtain 830 mg of the title compound as a yellow foamy solid.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-edc6aec86af149528e2a0491c8b65974
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329405B1

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