Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine

HRID 2269442노트

반응식

HRID 2269442 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)=O)=[CH:5][CH:4]=1.Cl.[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH2:35])[CH3:34])[CH:29]=[CH:30][C:31]=1[F:32].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH:35][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:34])[CH:29]=[CH:30][C:31]=1[F:32]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 18334221HCID 18334221, 화합물HCID 183471131-(3,4-Difluorophenyl)ethan-1-amine hydrochloride

생성물 1

HCID 18334197N-[1-(3,4-Difluorophenyl)ethyl]-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine수율 93.9%

시약·촉매·용매 2

HCID 24193Titanium Tetrachloride촉매HCID 176Acetic Acid용매

실험 절차

Following a similar procedure to that described in Example (1a), 700 mg of 3,4-dimethoxy-5-nitrophenyl 4-methoxyphenyl ketone, 854 mg of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 1.84 ml of triethylamine, 0.29 ml of titanium tetrachloride, 616 mg of sodium cyanoborohydride and 0.19 ml of acetic acid were reacted, to obtain 950 mg of the title compound as a yellow oil.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-8decf6faa133429cb06d4c5da8fa6cd9
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329405B1

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