Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine

HRID 2269463노트

반응식

HRID 2269463 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[F:20])=O)=[CH:5][CH:4]=1.Cl.[F:22][C:23]1[CH:24]=[C:25]([CH:30]([NH2:32])[CH3:31])[CH:26]=[CH:27][C:28]=1[F:29].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:22][C:23]1[CH:24]=[C:25]([CH:30]([NH:32][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[F:20])[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:31])[CH:26]=[CH:27][C:28]=1[F:29]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 183471131-(3,4-Difluorophenyl)ethan-1-amine hydrochlorideHCID 701897642-Fluoro-5-nitrophenyl 4-methoxyphenyl ketone

생성물 1

HCID 18334198N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine수율 68.7%

시약·촉매·용매 2

HCID 24193Titanium Tetrachloride촉매HCID 176Acetic Acid용매

실험 절차

Following a similar procedure to that described in Example (1a), 828 mg of 2-fluoro-5-nitrophenyl 4-methoxyphenyl ketone, 1.16 g of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 2.52 ml of triethylamine, 0.40 ml of titanium tetrachloride, 840 mg of sodium cyanoborohydride and 0.62 ml of acetic acid were reacted, to obtain 860 mg of the title compound as a yellow oil.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-ee39a17ebafd4c8897483ad36ca76c64
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329405B1

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