Hydrochloric Acid → HCID 86729745, 화합물

HRID 2272585노트

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HRID 2272585 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:17])[CH2:11][S:12][CH2:13][C:14]([OH:16])=O)=[CH:5][CH:4]=1)#[N:2].[CH2:18]([N:20]1[C:32]2[CH:31]=[CH:30][C:29]([NH2:33])=[CH:28][C:27]=2[C:26]2[C:21]1=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH3:19].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.Cl>CN(C=O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:17])[CH2:11][S:12][CH2:13][C:14]([NH:33][C:29]2[CH:30]=[CH:31][C:32]3[N:20]([CH2:18][CH3:19])[C:21]4[C:26]([C:27]=3[CH:28]=2)=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:16])=[CH:7][CH:8]=1)#[N:2]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 85883-Amino-9-ethylcarbazoleHCID 81531DiisopropylethylamineHCID 2812223HCID 2812223, 화합물HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 86729745HCID 86729745, 화합물수율 59%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of the compound obtained in Step 1 (145 mg, 0.58 mmol), 9-ethyl-9H-carbazol-3-amine (122 mg, 0.58 mmol), HATU (330 mg, 0.87 mmol) and DIEA (225 mg, 1.74 mmol) in DMF (4 mL) was stirred at room temperature for 16 hr. To the reaction solution was added dilute hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with dilute hydrochloric acid, and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the title compound (150 mg, 0.339 mmol, 59%) as a white powder.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with dilute hydrochloric acid
  3. customdried
  4. customthe solvent was evaporated under reduced pressure
  5. customThe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-9bdcbdd3da0f40cd92a4428eed8bf51f
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120776B2

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