Pyrrolidine → HCID 75480723, 화합물
반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>O>[N+:8]([C:5]1[CH:4]=[CH:3][C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][N:6]=1)([O-:10])=[O:9]참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 600 mg (2.93 mmol) of 5-bromo-2-nitropyridine and 1.05 g (14.63 mmol) of pyrrolidine is heated in a Biotage microwave machine for 1 hour at 120° C. The reaction medium is diluted with water and then extracted with ethyl acetate. The organic phase is washed twice with water, dried over MgSO4 and then filtered. The filtrate is evaporated under reduced pressure and then chromatographed on silica gel, eluting with a heptane/ethyl acetate mixture from (100/0 v/v) up to (50/50 v/v) to give 410 mg of 2-nitro-5-pyrrolidin-1-ylpyridine.
후처리
- extractionextracted with ethyl acetate
- washThe organic phase is washed twice with water
- dry with materialdried over MgSO4
- filtrationfiltered
- customThe filtrate is evaporated under reduced pressure
- customchromatographed on silica gel
- washeluting with a heptane/ethyl acetate mixture from (100/0 v/v) up to (50/50 v/v)
출처 및 근거
- ORD 기록
- ord-1d08bca20e5545d0b70ccbdc23196acb
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09120812B2
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