Sodium Hydroxide → 4-Bromo-1-N-isopropylbenzene-1,2-diamine

HRID 2273599노트

반응식

HRID 2273599 반응식
[Sn](Cl)Cl.[Br:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][CH:10]([CH3:12])[CH3:11])=[C:7]([N+:15]([O-])=O)[CH:6]=1.[OH-].[Na+]>C(O)C>[Br:4][C:5]1[CH:6]=[C:7]([NH2:15])[C:8]([NH:9][CH:10]([CH3:11])[CH3:12])=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 2759489N-Isopropyl 4-bromo-2-nitroaniline

생성물 1

HCID 337851464-Bromo-1-N-isopropylbenzene-1,2-diamine수율 75.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Tin(II) chloride (1.69 g, 8.90 mmol) is added to a solution of 4-bromo-N-isopropyl-2-nitroaniline (770 mg, 2.97 mmol) in ethanol. The mixture may be heated to reflux for an appropriate time (such as 4 hr) and cooled. 4 N sodium hydroxide is added to the solution which then may be filtered. The filtrate is extracted with ethyl acetate. The combined organic layer may be washed with brine and concentrated. The residue may be purified by any appropriate method including Biotage column chromatography to give 4-bromo-N-1-isopropylbenzene-1,2-diamine (513 mg).

후처리

  1. temperatureThe mixture may be heated
  2. temperatureto reflux for an appropriate time (such as 4 hr)
  3. temperaturecooled
  4. filtrationmay be filtered
  5. extractionThe filtrate is extracted with ethyl acetate
  6. washThe combined organic layer may be washed with brine
  7. concentrationconcentrated
  8. customThe residue may be purified by any appropriate method

출처 및 근거

ORD 기록
ord-50117e9834364446a613ddda7fb0c1f0
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09125901B2

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