N-bromobutanimide → 2-Amino-5-bromo-4-methoxybenzaldehyde

HRID 2274216

반응식

HRID 2274216 반응식
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 3235032-Amino-4-methoxybenzaldehyde

생성물 1

HCID 593252582-Amino-5-bromo-4-methoxybenzaldehyde수율 56%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231. Found: 230, 232 [M+H]+.

후처리

  1. customthe reaction until the starting material
  2. customconsumed completely
  3. additionThe reaction mixture was diluted with dichloromethane and water
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-13f9a284f91e4c41937f53b20427825b
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126951B2

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