Sodium Hydroxide → N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine

HRID 2276395노트

반응식

HRID 2276395 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.[OH-:13].[Na+].[NH2:15]O.Cl>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[N:15][OH:13]

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 679903-(Trifluoromethyl)benzaldehydeHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 2777383N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine수율 93.5%

실험 절차

In a similar manner as described in Preparation Example 1, by using 3-(trifluoromethyl)benzaldehyde (34.82 g, 200.0 mmol), sodium hydroxide (12.00 g, 300.0 mmol) and hydrochloric acid hydroxylamine (16.68 g, 240 mmol), a white solid required compound (35.33 g, 187 mmol, 93%) was obtained.

후처리

  1. customIn a similar manner as described in Preparation Example 1

출처 및 근거

ORD 기록
ord-49dfc682bb7a436ca053255ec074e786
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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