Methanol → (2-Methylpyrimidin-5-yl)methanol

HRID 2278727

반응식

HRID 2278727 반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][N:3]=1.CO.[BH4-].[Na+]>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][N:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 31609702-Methylpyrimidine-5-carbaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 14686706(2-Methylpyrimidin-5-yl)methanol

실험 절차

A solution of 2-methylpyrimidine-5-carbaldehyde (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0° C. and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.

후처리

  1. customthe reaction was quenched with eq H2O (200 mL)
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-de2a0261964e47fdbe979956c4b1a68e
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133122B2

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