Hydrochloric Acid → (2R)-2-acetamido-3-methoxypropanoic acid

HRID 2280359노트

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HRID 2280359 반응식
[C:1]([NH:4][CH:5]([C:9]([OH:11])=[O:10])[CH2:6][O:7][CH3:8])(=[O:3])[CH3:2].[OH-].[Na+].Cl>O>[C:1]([NH:4][C@H:5]([CH2:6][O:7][CH3:8])[C:9]([OH:11])=[O:10])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 189180482-Acetamido-3-methoxypropanoic acid

생성물 1

HCID 10558933(2R)-2-acetamido-3-methoxypropanoic acid수율 50%

시약·촉매·용매 1

HCID 962Water용매

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온도
25 °C

실험 절차

In a vessel, equipped with a magnetic stirrer and pH controller, N-acetyl-O-methyl-D,L-serine (3 g) was dissolved in demineralized water (30 mL) and the pH was adjusted to 7.5-8.0 with 5N sodium hydroxide solution. Acylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added and the solution maintained at 25° C. under mild agitation overnight. The pH was adjusted to 2.7 with concentrated HCl and the aqueous solution injected onto Dowex™ 50WX4-50 ion exchange resin (50 mL) conditioned at pH 3.8. The resulting material was eluted with water at pH 2.4. The aqueous solution thereby obtained was then evaporated to dryness under vacuum to afford the title compound (1.5 g, 50%) as an off-white solid.

후처리

  1. customIn a vessel, equipped with a magnetic stirrer
  2. additionAcylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added
  3. washThe resulting material was eluted with water at pH 2.4
  4. customThe aqueous solution thereby obtained
  5. customwas then evaporated to dryness under vacuum

출처 및 근거

ORD 기록
ord-d3a07d20d77c47be9b81a14f76a28436
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139513B2

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