Hydrochloric Acid → 8-Fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one
반응식
Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[F:14])=[O:5].[Al+3].[Cl-].[Cl-].[Cl-].Cl>>[F:14][C:8]1[CH:9]=[C:10]([OH:13])[CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[CH2:3][CH2:2]2참가 물질
4
반응 조건
- 온도
- 160 °C
실험 절차
3-Chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide (2.1 g) was mixed with anhydrous AlCl3 (7 g) and heated at 160° C. overnight. The resultant mixture was treated with 1N HCl and extracted with EtOAc. After isolation of the organic layer and removal of solvents under reduced pressure, the desired crude product (1.8 g) was collected as light brown solids.
후처리
- extractionextracted with EtOAc
- customAfter isolation of the organic layer and removal of solvents under reduced pressure
- customthe desired crude product (1.8 g) was collected as light brown solids
출처 및 근거
- ORD 기록
- ord-1dc77d2b00d14028b67f1f5f13ce41e6
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09139528B2
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