Hydrochloric Acid → HCID 67464347, 화합물

HRID 2281176노트

반응식

HRID 2281176 반응식
[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[N:12](S(C4C=CC=CC=4)(=O)=O)[C:11]=23)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl>CS(C)=O.O>[C:1]1([C:7]2[O:8][CH:9]=[C:10]3[C:18]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[NH:12][C:11]=23)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 104070034H-Furo[3,4-b]indole, 3-phenyl-4-(phenylsulfonyl)-

생성물 1

HCID 67464347HCID 67464347, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

45 g (123 mmol) of 3-phenyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole and 48 g (856 mmol) of potassium hydroxide in 65 ml of DMSO and 21 ml of water are heated under reflux for 1 h. The mixture is subsequently cooled to room temperature, neutralised using 1M HCl solution and extracted with dichloromethane. The solvent is evaporated in vacuo, and the residue is purified by chromatography (heptane/ethyl acetate 10:1). Yield: 22.4 g (96 mmol), 80%.

후처리

  1. temperatureunder reflux for 1 h
  2. extractionextracted with dichloromethane
  3. customThe solvent is evaporated in vacuo
  4. customthe residue is purified by chromatography (heptane/ethyl acetate 10:1)

출처 및 근거

ORD 기록
ord-a0631ac15b5a422ba9876dcaa1b17a25
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139582B2

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