Lithium Hydroxide → 4-Amino-3-iodobenzoic Acid
반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[I:12].[OH-].[Li+]>O1CCOCC1.O>[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[I:12]참가 물질
4
실험 절차
A solution of 3.00 g (10.8 mmol) of methyl 4-amino-3-iodobenzoate and 1.30 g (54.1 mmol) of lithium hydroxide in 150 ml of a dioxane/water mixture (1:1) was stirred at room temperature for 6 h. The dioxane was distilled off in vacuo, and the remaining aqueous phase was adjusted to pH 5 with 1 M hydrochloric acid. The precipitate was filtered off with suction and washed with water. 2.80 g (98%) of the title compound were obtained as a solid.
후처리
- distillationThe dioxane was distilled off in vacuo
- filtrationThe precipitate was filtered off with suction
- washwashed with water
출처 및 근거
- ORD 기록
- ord-26e48a7e62ea4df790bada8bd6c49550
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09139579B2
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