4-Chloro-6,7-dimethoxyquinoline → 6-Methyl-2-pyridinecarboxaldehyde
반응식
ClC1C2C(=CC(OC)=C(OC)C=2)N=CC=1.O[C:17]1[C:18]([CH:24]=[O:25])=[N:19][C:20]([CH3:23])=[CH:21][CH:22]=1>CN(C)C1C=CN=CC=1.ClC1C=CC=CC=1Cl>[CH3:23][C:20]1[N:19]=[C:18]([CH:24]=[O:25])[CH:17]=[CH:22][CH:21]=1참가 물질
5
반응 조건
- 온도
- 150 °C
실험 절차
4-Chloro-6,7-dimethoxyquinoline (330 mg), 3-hydroxy-6-methyl-2-pyridinecarbaldehyde (200 mg), and 4-dimethylaminopyridine (360 mg) were suspended in o-dichlorobenzene (7 ml), and the suspension was stirred at 150° C. for 3 hr. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-chloroform to give 3-[6,7-dimethoxy-4-quinolyl]oxy}-6-methyl-2-pyridinecarbaldehyde (24 mg, yield 5%).
후처리
- temperatureThe reaction solution was cooled to room temperature
- customwas then purified by column chromatography
출처 및 근거
- ORD 기록
- ord-4db4ba8d7bab46529eeeeb2c47d6995c
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07560558B2
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