(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol → (4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone

HRID 228796

반응식

HRID 228796 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)=[O:9])[O:5][C:6]=1[CH3:7]

참가 물질

4

반응물 1

HCID 23078354(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol

생성물 1

HCID 23078247(4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone수율 97.1%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol (945 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.5 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone (910 mg, yield 97%).

후처리

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

출처 및 근거

ORD 기록
ord-ff9c0126c13c495080a3055c9946dee9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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