Sodium Hydroxide → 7-Methylquinolin-6-ol

HRID 228868

반응식

HRID 228868 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][CH:7]=[CH:6]2.[OH-].[Na+].C(=O)([O-])O.[Na+]>Br(O)(=O)=O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][CH:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 155348986-Methoxy-7-methylquinoline

생성물 1

HCID 128389567-Methylquinolin-6-ol수율 47.2%

시약·촉매·용매 1

HCID 24445Bromic acid용매

실험 절차

6-Methoxy-7-methyl-quinoline (3 g) was added to an aqueous bromic acid solution (30 ml), and the mixture was heated under reflux for 7 hr. The reaction solution was cooled to room temperature, the aqueous layer was then neutralized with an aqueous sodium hydroxide solution and an aqueous sodium hydrogencarbonate solution. The organic layer was extracted with ether, the solvent was removed by distillation under the reduced pressure, and the residue was washed with cooled ether to give 6-hydroxy-7-methylquinoline (1.3 g, yield 47%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 7 hr
  3. extractionThe organic layer was extracted with ether
  4. customthe solvent was removed by distillation under the reduced pressure
  5. washthe residue was washed with cooled ether

출처 및 근거

ORD 기록
ord-a88db85475c740678b93231be4afa665
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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