2-Chloroaniline → 8-Chloro-2-methylquinoline

반응식

[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH:9](=O)/[CH:10]=[CH:11]/[CH3:12]>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[C:11]([CH3:12])[CH:10]=[CH:9]2

참가 물질

반응물 2

HCID 72402-Chloroaniline

HCID 447466Crotonaldehyde

생성물 1

HCID 2211138-Chloro-2-methylquinoline수율 57%

실험 절차

The procedure described in Example 1 was followed, except that 130 g/hour of 2-chloroaniline and 84 g/hour of crotonaldehyde were employed. Distillation from the oil bed under 5 mbar until the bottom temperature reached 250° C., and crystallization of the distillate with xylene, gave 101 g (57% of theory) of 8-chloro-2-methylquinoline of melting point 64° C.

후처리

distillationDistillation from the oil bed under 5 mbar until the bottom temperature
customreached 250° C.
customcrystallization of the distillate with xylene

출처 및 근거

ORD 기록: ord-da50df8f3f3f4fb78c0fb85de7b18430
출처 데이터셋: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04617395

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