Triethylamine → 3-{4-[3-(4-Chlorophenyl)propyl]piperazin-1-yl}propanethiol dihydrochloride

HRID 2290884노트

반응식

HRID 2290884 반응식
NC(N)=[S:3].[ClH:5].Cl.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][N:20]([C:23]3C=CC=[C:25](Cl)[CH:24]=3)[CH2:19][CH2:18]2)=[CH:10][CH:9]=1.C(N(CC)CC)C.[OH-].[Na+]>O.C(O)C>[ClH:7].[ClH:5].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][SH:3])[CH2:19][CH2:18]2)=[CH:10][CH:9]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 201531861-[3-(4-Chlorophenyl)propyl]-4-(3-chlorophenyl)piperazine dihydrochloride

생성물 1

HCID 137311303-{4-[3-(4-Chlorophenyl)propyl]piperazin-1-yl}propanethiol dihydrochloride수율 134.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

The procedure described in Example 1(b) was followed, using 7.6 g of thiourea, 22.9 g of 1-[3-(4-chlorophenyl)propyl]-4-(3-chlorophenyl)piperazine dihydro- chloride, 5.8 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 14.1 g (65% of theory) of 3-{4-[3-(4-chlorophenyl)propyl]piperazin-1-yl}propanethiol dihydrochloride as a white crystalline solid, M.p. 238°-242° C.

출처 및 근거

ORD 기록
ord-152dfbf2cdd94c24afddfd62c26a9ca9
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618677

반응 노트

불러오는 중…