L-Alanine → (S)-2-(phenylsulfonamido)propanoic acid

HRID 2290957노트

반응식

HRID 2290957 반응식
[NH2:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[C:7]1([S:13](Cl)(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>[OH-].[Na+]>[C:7]1([S:13]([NH:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3])(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 5950L-AlanineHCID 7369Benzenesulfonyl chloride

생성물 1

HCID 7114743(S)-2-(phenylsulfonamido)propanoic acid수율 95%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

N-benzenesulfonylalanine was prepared by mixing equimolar quantities of alanine and benzenesulfonyl chloride at 60° C. in aqueous sodium hydroxide (200 mol%). A 95% yield was obtained. The method is set out in the previously mentioned book "Chemistry Of The Amino Acids".

후처리

  1. customA 95% yield was obtained

출처 및 근거

ORD 기록
ord-426399edc266420e8327c4a0943796f2
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618710

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