Hydrochloric Acid → Imazaquin

HRID 2291804

반응식

HRID 2291804 반응식
[C:1]([C:4]([NH:9][C:10]([C:12]1[C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1)=O)([CH3:8])[CH:5]([CH3:7])[CH3:6])(=[O:3])[NH2:2].[OH-].[Na+].Cl>O>[CH:5]([C:4]1([CH3:8])[C:1](=[O:3])[NH:2][C:10]([C:12]2[C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[N:9]1)([CH3:7])[CH3:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 134747362-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid

생성물 1

HCID 54739Imazaquin

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 2-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid (0.152 mol), in water (50 ml) containing sodium hydroxide (0.06 mol) is heated at 75° to 80° C. for 2 hours. The solution is cooled in an ice bath and acidified with concentrated hydrochloric acid, added in small increments. The resulting precipitate is filtered, washed with water, air dried, and recrystallized from acetone to afford the 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, mp 239°-243.5° C.

후처리

  1. temperatureis heated at 75° to 80° C. for 2 hours
  2. temperatureThe solution is cooled in an ice bath
  3. additionadded in small increments
  4. filtrationThe resulting precipitate is filtered
  5. washwashed with water, air
  6. customdried
  7. customrecrystallized from acetone

출처 및 근거

ORD 기록
ord-1076902384594129bab1e06e4c600461
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04798619

연결된 노트

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