Hydrochloric Acid → 1-[5-Hydroxy-2-(phenylethynyl)phenyl]-2-propanone

HRID 2291904노트

반응식

HRID 2291904 반응식
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:15]#[C:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([CH2:11][C:12](=[O:14])[CH3:13])[CH:10]=1)(=O)C.[OH-].[Na+].Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([C:15]#[C:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:9]([CH2:11][C:12](=[O:14])[CH3:13])[CH:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 212782901-[5-Acetoxy-2-(phenylethynyl)phenyl]-2-propanone

생성물 1

HCID 212782891-[5-Hydroxy-2-(phenylethynyl)phenyl]-2-propanone수율 101%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-[5-Acetoxy-2-(phenylethynyl)phenyl]-2-propanone (3.3 g, 11 mmole) was dissolved in MeOH (15 mL) and treated with 50% sodium hydroxide solution (1.8 g, 22 mmole) under argon. The reaction was stirred for 1 hr then poured into dilute hydrochloric acid and extracted with diethyl ether. The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The product was dried under vacuum to yield 2.78 g (98%) of the title compound.

후처리

  1. extractionextracted with diethyl ether
  2. washThe combined organic extracts were washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe product was dried under vacuum

출처 및 근거

ORD 기록
ord-d5c60c1579594ad2a2cbc52e098f12ea
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04798893

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