Phenol → Phenyl phenylacetate

HRID 2292121노트

반응식

HRID 2292121 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([CH2:14][C:15](Cl)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl.N1C=CC=CC=1>[C:8]1([CH2:14][C:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 2

HCID 996PhenolHCID 7679Phenylacetyl chloride

생성물 1

HCID 164721Phenyl phenylacetate수율 95.6%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

Phenol (47.9 g) was dissolved in dichloromethane (250 ml) and pyridine (44.3 g). Phenylacetyl chloride (78.8 g) was added with stirring over 40 min., and the resulting mixture allowed to stand at room temperature for 1 hr. The mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution, and then once with saturated brine. The solution was dried and evaporated to give phenyl phenylacetate 103.3 g., m.pt 39°-41°.

후처리

  1. waitto stand at room temperature for 1 hr
  2. washThe mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution
  3. customThe solution was dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-021f2ec649524e079520067619bd1e06
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04801593

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