Hydrochloric Acid → 3-Hydroxy-4-phenylaminopyrrolidine hydrochloride
반응식
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1참가 물질
4
실험 절차
In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.
후처리
- customobtained
- additionwas added
- temperatureAfter the mixture was refluxed
- temperatureby heating for 2.5 hours
- customthe solvent was removed under reduced pressure
- washThe resulting residue was washed with ethanol and ether
출처 및 근거
- ORD 기록
- ord-00670e6f07064619996405877f3459db
- 출처 데이터셋
- uspto-grants-1997_11
- 특허 번호
- US05688791
반응 노트
불러오는 중…