Hydrochloric Acid → 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride

HRID 2294009

반응식

HRID 2294009 반응식
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1.[ClH:26]>C(O)C>[ClH:26].[ClH:26].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 98623392-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine

생성물 1

HCID 214737112-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride수율 94.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

후처리

  1. customthe residue was recrystallized from ethanol/diethyl ether

출처 및 근거

ORD 기록
ord-aa119e3e72dc4c73b0141cc73f0aba92
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

연결된 노트

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