Hydrochloric Acid → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294037

반응식

HRID 2294037 반응식
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[ClH:23]>CO>[ClH:23].[ClH:23].[C:1]1([CH3:22])[CH:2]=[CH:3][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 214736335-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

생성물 1

HCID 214736325-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride수율 77%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.23 g (0.00077 mol) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.44 ml (0.00154 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.22 g (77%) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as whited crystals; m.p. 220°-222°.

후처리

  1. customthe residue was recrystallized from ethanol/diethyl ether

출처 및 근거

ORD 기록
ord-60f3192f14224afc936563c5caeac9ae
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

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