2-Chloro-4-nitrobenzonitrile → 4-Amino-2-chlorobenzonitrile

HRID 2295372

반응식

HRID 2295372 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>O.NN>[Cl:1][C:2]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

3

반응물 1

HCID 1414012-Chloro-4-nitrobenzonitrile2회

생성물 1

HCID 887284-Amino-2-chlorobenzonitrile수율 598.3%

시약·촉매·용매 1

HCID 24654Hydrazine hydrate (1:1)용매

실험 절차

A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78%, mp 117° C.).

후처리

  1. temperaturethe reaction mixture was refluxed approximately thirty minutes
  2. additionpoured
  3. filtrationThe precipitate was filtered
  4. customthe solid was crystallized from water

출처 및 근거

ORD 기록
ord-00dd216749eb4b8bb83edd99435101ce
출처 데이터셋
uspto-grants-1984_01
특허 번호
US04424371

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