Sulfuric Acid → 2-hydroxyimino-N-phenylacetamide

HRID 2298014

반응식

HRID 2298014 반응식
[C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])[CH2:2]C(C)=O.[N:14]([O-])=[O:15].[Na+].S(=O)(=O)(O)O>[OH-].[Na+]>[OH:15][N:14]=[CH:2][C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 7592AcetoacetanilideHCID 23668193Sodium Nitrite

생성물 1

HCID 63990632-hydroxyimino-N-phenylacetamide수율 98.5%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
0 °C

실험 절차

Acetoacetanilide (25.0 g, 0.14 mol) and sodium nitrite (12.65 g, 0.18 mol) were dissolved in aqueous sodium hydroxide solution (140 ml, 1 N) and the resulting solution was added dropwise over 20 min to an aqueous solution of sulfuric acid (120 ml conc. H2SO4 in 950 ml water) cooled in an ice bath. The reaction mixture was stirred at 0° C. for 30 min, then the precipitate was filtered and washed with water to yield 2-hydroxyiminoacetanilide (22.64 g, 78% yield) as a pale yellow solid.

후처리

  1. temperaturecooled in an ice bath
  2. filtrationthe precipitate was filtered
  3. washwashed with water

출처 및 근거

ORD 기록
ord-c916ce4de7414023bfc41ad8ba0d765e
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06492401B1

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