Methyl acetoacetate → 2-Methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide

HRID 229863

반응식

HRID 229863 반응식
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][C:20]([F:23])([F:22])[F:21])=O.[CH2:24]([NH2:30])[C@@H:25]1[O:29][CH2:28][CH2:27][CH2:26]1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21])[N:30]([CH2:24][C@H:25]3[CH2:26][CH2:27][CH2:28][O:29]3)[C:5]=2[CH3:6])=[O:2])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

참가 물질

5

반응물 4

HCID 7757Methyl acetoacetateHCID 7965CyclohexylamineHCID 2734124(R)-(-)-TetrahydrofurfurylamineHCID 27786842-(Trifluoromethoxy)phenacyl bromide

생성물 1

HCID 115468772-Methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide

실험 절차

The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-(trifluoromethoxy)phenyl]-ethanone as compound of formula S, (R)-tetrahydrofurfurylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 451.5 (M+H)+.

출처 및 근거

ORD 기록
ord-19c79007c6d644dc8efceb46f516b0ed
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07563910B2

연결된 노트

불러오는 중…