Hydrochloric Acid → 3-(Diethylsulfamoyl)benzoic acid

HRID 2300765

반응식

HRID 2300765 반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15].Cl>C(Cl)Cl>[CH2:14]([N:16]([CH2:17][CH3:18])[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH3:15]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 77641Benzoic acid, 3-(chlorosulfonyl)-

생성물 1

HCID 7945953-(Diethylsulfamoyl)benzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of 3-(chlorosulfonyl)benzoic acid (1.02 g, 4.62 mmol) in CH2Cl2 (100 mL) at 0° C. was added diethylamine (2.4 mL, 23 mmol). The resulting mixture was stirred at 0° C. for 3 h then worked up by adding 2N aqueous HCl and extracting 3× with EtOAc. The combined organic was washed with brine then dried over MgSO4 and concentrated under reduced pressure. The residue was used without further purification.

후처리

  1. extractionextracting 3× with EtOAc
  2. washThe combined organic was washed with brine
  3. dry with materialthen dried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was used without further purification

출처 및 근거

ORD 기록
ord-90ed747076b34b5eba680df517cd9781
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06498165B1

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