Hydrogen Bromide → 4,5,6,7-Tetrahydrothieno(3,2-c)pyridine

HRID 2301108노트

반응식

HRID 2301108 반응식
Cl.[S:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[CH:4]=[C:3]1C(O)=O.Br.[OH-].[Na+]>>[S:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[CH:4]=[CH:3]1

참가 물질

4

반응물 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 686439894,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

생성물 1

HCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridine

실험 절차

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (260 mg, 1.2 mmol) was mixed with 47% hydrogen bromide aqueous solution (3 ml) and heated under reflux for 4 hours. The reaction solution was returned to room temperature and alkalified by adding sodium hydroxide aqueous solution (5 N), and the reaction product was extracted with diethyl ether, washed with saturated brine and then dried with anhydrous magnesium sulfate. By evaporating the solvent from the organic layer under a reduced pressure, 160 mg (1.1 mmol, 95% in yield) of the title compound was obtained.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. customwas returned to room temperature
  4. extractionthe reaction product was extracted with diethyl ether
  5. washwashed with saturated brine
  6. dry with materialdried with anhydrous magnesium sulfate
  7. customBy evaporating the solvent from the organic layer

출처 및 근거

ORD 기록
ord-ef3905e6c0ad4871b5362ba542da70ed
출처 데이터셋
uspto-grants-2002_12
특허 번호
US06498251B1

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