DL-alanine → 2-Methylpropyl 2-aminopropanoate hydrochloride

HRID 23018

반응식

HRID 23018 반응식
[NH2:1][CH:2]([C:4]([OH:6])=[O:5])[CH3:3].S(Cl)([Cl:9])=O.[CH2:11](O)[CH:12]([CH3:14])[CH3:13]>>[ClH:9].[CH2:11]([O:5][C:4](=[O:6])[CH:2]([CH3:3])[NH2:1])[CH:12]([CH3:14])[CH3:13]

참가 물질

4

반응물 3

HCID 602DL-alanineHCID 6560IsobutanolHCID 24386Thionyl Chloride

생성물 1

HCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

실험 절차

A mixture of 35.64 g (0.4 mol) of D,L-alanine (Aldrich), 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of iso-butanol was refluxed for 1.5 hours. The volatiles were removed at reduced pressure at 90° C. under reduced pressure to give the title compound as an oil, which was used without further purification.

후처리

  1. temperaturewas refluxed for 1.5 hours
  2. customThe volatiles were removed at reduced pressure at 90° C. under reduced pressure

출처 및 근거

ORD 기록
ord-4925e8544ee04f8dbe2b5bf9ea58b95b
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849650B2

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