Pyridine → Isobutyl 2-bromopropionate
반응식
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]참가 물질
5
실험 절차
To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.
후처리
- washwashed with 1N HCl, water, aqueous NaHCO3, brine
- dry with materialdried over magnesium sulfate or sodium sulfate
- customRemoval of the solvents at reduced pressure
출처 및 근거
- ORD 기록
- ord-3f7d1b842cd34c0a9f136902c629ac0f
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06849650B2
반응 노트
불러오는 중…