Dimethylformamide → 8-Hydroxyjulolidine

HRID 2303939

반응식

HRID 2303939 반응식
N[C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][CH2:12]Cl.[CH3:14][N:15]([CH3:18])[CH:16]=O>>[CH2:10]1[CH2:18][N:15]2[C:14]3[C:5]([CH2:6][CH2:7][CH2:16]2)=[C:4]([OH:8])[CH:3]=[CH:2][C:12]=3[CH2:11]1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 80061-Bromo-3-chloropropaneHCID 115683-Aminophenol

생성물 1

HCID 1704748-Hydroxyjulolidine수율 62%

실험 절차

According to a procedure similar to that of Embodiment 1, a mixture of m-aminophenol (5.0 g, 46 mmol), 1 -bromo-3-chloropropane (23.9 g, 15 ml, 151 mmol) and N,N-dimethylformamide (15 ml) was heated and refluxed for 15 hours. After silica gel column chromatography, 8-hydroxyjulolidine (5.5 g) was obtained in 62% yield.

후처리

  1. temperaturewas heated
  2. temperaturerefluxed for 15 hours

출처 및 근거

ORD 기록
ord-80264873ef544886a3d4602d8773d5de
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06433176B1

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