Ethanol → 8-Hydroxyjulolidine

HRID 2303941

반응식

HRID 2303941 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][CH2:12]Cl.[C:14]([O-])(O)=O.[Na+].[CH2:19](O)[CH3:20]>>[CH2:11]1[CH2:12][N:1]2[C:2]3[C:3]([CH2:14][CH2:19][CH2:20]2)=[C:4]([OH:8])[CH:5]=[CH:6][C:7]=3[CH2:10]1

참가 물질

5

반응물 4

HCID 702EthanolHCID 80061-Bromo-3-chloropropaneHCID 115683-AminophenolHCID 516892Sodium Bicarbonate

생성물 1

HCID 1704748-Hydroxyjulolidine수율 39%

실험 절차

According to a procedure similar to that of Embodiment 5, a mixture of m-aminophenol (5.0 g, 45.8 mmol), 1-bromo-3-chloropropane (23.9 g, 15 ml, 150 mmol) and ethanol (50 ml) was heated and refluxed. NaHCO3 (10.0 g, 119 mmol) aqueous solution (20 ml) was added slowly. After 24 hours of reflux, 3.4 g of 8-hydroxyjulolidine was obtained in 39% yield.

후처리

  1. temperaturewas heated
  2. temperaturerefluxed
  3. temperatureAfter 24 hours of reflux

출처 및 근거

ORD 기록
ord-a5fd6cbee54040239240a353d2500eff
출처 데이터셋
uspto-grants-2002_08
특허 번호
US06433176B1

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