p-Toluidine → HCID 178424384, 화합물

반응식

[C:1]1([CH3:14])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][N:8]=[C:9]([C:12]#[N:13])[C:10]#[N:11].NC1C=CC(C)=CC=1.C(#N)CC#N.O.[NH2:29][NH2:30]>>[NH2:11][C:10]1[C:9](=[N:8][NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:14])[C:12]([NH2:13])=[N:30][N:29]=1

참가 물질

반응물 4

HCID 7813p-Toluidine

HCID 8010Malononitrile

HCID 24654Hydrazine hydrate (1:1)

HCID 12450559Carbonylcyanide2methylphenylhydrazone

생성물 1

HCID 178424384HCID 178424384, 화합물수율 40%

실험 절차

This compound was prepared using 92 mg (0.5 mmol) of 2-(o-tolylhydrazono)-malononitrile, which was derived from 4-toluidine (107 μL, 1.0 mmol) and malononitrile (1.5 mmol) as described in Example 8, and hydrazine hydrate. Very little solid had formed after heating the reaction at 75° C. for 1 hr, however, analysis of the reaction solution by TLC indicated that no starting material remained. The solution was allowed to cool to room temperature and the solvent was evaporated. The residue was dissolved in ethyl acetate and then precipitated by the addition of hexanes. The resulting solid was isolated by filtration and dried to yield 43 mg (40%) of the title compound as a yellow solid.