Acetic Anhydride → Methyl 4-acetoxyindole-2-carboxylate
반응식
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13][CH3:14])=[O:12])[NH:6]2.[C:15](OC(=O)C)(=[O:17])[CH3:16]>CN(C)C1C=CN=CC=1>[C:15]([O:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13][CH3:14])=[O:12])[NH:6]2)(=[O:17])[CH3:16]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
Methyl 4-hydroxyindole-2-carboxylate (0.5 g) and 4-dimethylaminopyridine (50 mg) were dissolved in acetic anhydride (5 ml) and heated at 80° C. for 3 hours. The reaction was allowed to cool overnight to precipitate white crystals, which were filtered and dried in vacuo (0.44 g, 72%); NMR δ(CD3SOCD3) 2.34 (s, 3H), 3.85 (s, 3H), 6.80 (d, 1H) 7.06 (s, 1H), 7.23 (t, 1H), 7.29-7.35 (m, 1H), 12.1 (bs, 1H); M/z (−) 232 (M−H+).
후처리
- temperatureto cool overnight
- customto precipitate white crystals, which
- filtrationwere filtered
- customdried in vacuo (0.44 g, 72%)
출처 및 근거
- ORD 기록
- ord-8bc9d93077464320a01e9aaf31c74108
- 출처 데이터셋
- uspto-grants-2002_08
- 특허 번호
- US06441004B1
반응 노트
불러오는 중…