Ethanol → HCID 136347709, 화합물

HRID 2306660노트

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HRID 2306660 반응식
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].CCO.Cl.[NH2:19][OH:20]>[OH-].[Na+]>[OH:14][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:4]=1[C:1](=[N:19][OH:20])[CH3:2])[C:8]([O:10][CH3:11])=[O:9]

참가 물질

5

반응물 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 22610067Methyl 4-acetyl-3-hydroxybenzoate

생성물 1

HCID 136347709HCID 136347709, 화합물수율 78.1%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Methyl 4-acetyl-3-hydroxybenzoate (350 mg, 1.8 mmole) is combined with 5 ml absolute EtOH. The solution is treated with hydroxylamine hydrochloride (125 mg, 1.8 mmole) dissolved in 0.9 ml 2N aqueous NaOH, and the reaction is stirred overnight at rt. The volatiles are removed in vacuo and the residue is washed with H2O, collected, and dried to give 294 mg (78%) of methyl 3-hydroxy-4-[N-hydroxyethanimidoyl]benzoate as a tan solid. MS (EI) m/z: 209 (M+).

후처리

  1. customThe volatiles are removed in vacuo
  2. washthe residue is washed with H2O
  3. customcollected
  4. customdried

출처 및 근거

ORD 기록
ord-21289b0afe6342acbdf4645abada056c
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06828330B2

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