Hydrazine hydrate (1:1) → 3-Phenyl-4,5-dihydro-1H-pyrazole

HRID 2307257

반응식

HRID 2307257 반응식
O.[NH2:2]N.C[N:5]([CH2:7][CH2:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)C>C(O)C>[C:11]1([C:9]2[CH2:8][CH2:7][NH:5][N:2]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 770423-(Dimethylamino)-1-phenyl-1-propanone

생성물 1

HCID 5897453-Phenyl-4,5-dihydro-1H-pyrazole수율 89.8%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Hydrazine monohydrate (6.2 g) was dissolved in ethanol (12 ml). Thereto was dropwise added a solution of 3-(N,N-dimethylamino)propiophenone (5.4 g) dissolved in ethanol (10 ml) in a nitrogen atmosphere at room temperature. The resulting mixture was refluxed for 3 hours with heating. The reaction mixture was poured into ice water. Extraction with chloroform was conducted, followed by drying and concentration, to obtain 4 g of a title compound.

후처리

  1. temperatureThe resulting mixture was refluxed for 3 hours
  2. temperaturewith heating
  3. extractionExtraction with chloroform
  4. customby drying
  5. concentrationconcentration

출처 및 근거

ORD 기록
ord-83a156f60c7b4a8db71824ec8e439b8f
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06831083B2

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