Hydrochloric Acid → 2-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiophene

HRID 230883노트

반응식

HRID 230883 반응식
[CH3:1][O:2][C:3]1[C:11]2[C:10]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:9]([C:20]([O:22]C)=[O:21])[S:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.CO.[OH-].[Na+].Cl>O1CCCC1>[C:20]([C:9]1[S:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[C:10]=1[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([OH:22])=[O:21]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 231035484-Methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene

생성물 1

HCID 231035202-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiophene수율 95.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene (1.09 g) in tetrahydrofuran (6 mL)-methanol (21 mL) was added 1 mol/L aqueous sodium hydroxide solution (21 mL), and the mixture was heated for reflux for 3.5 hours. The reaction mixture was cooled to room temperature. To the mixture was added 2 mol/L hydrochloric acid (11 mL), and the precipitated crystals were collected by filtration. The crystals were dried under reduced pressure to give the title compound (1 g).

후처리

  1. temperaturethe mixture was heated
  2. temperaturefor reflux for 3.5 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. customThe crystals were dried under reduced pressure

출처 및 근거

ORD 기록
ord-577da371a756430ebeb9460efc8effec
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566699B2

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