Water → 6'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

HRID 230893

반응식

HRID 230893 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21].O>CC(C)=O>[OH:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[C:4]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 696872',6'-Dihydroxyacetophenone

생성물 1

HCID 105370846'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixture of 2′,6′-dihydroxyacetophenone (6 g) and potassium carbonate (5.72 g) in acetone (20 mL) was added methyl bromoacetate (3.73 mL), and the mixture was stirred at room temperature for 5 days. To the reaction mixture was added water, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (7.89 g).

후처리

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-9697439f8c5f4eaf8fdafdd370708a5d
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566699B2

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