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Hydrochloric Acid → HCID 20033758, 화합물

HRID 2309216
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HRID 2309216 반응식
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.C(N(CC)C(C)C)(C)C.[Cl:19][S:20]([C:23]1[CH:32]=[CH:31][CH:30]=[C:29]([N+:33]([O-:35])=[O:34])[C:24]=1[C:25]([O:27][CH3:28])=[O:26])(=[O:22])=[O:21].Cl>O1CCCC1>[ClH:19].[N:4]1([CH2:3][CH2:2][NH:1][S:20]([C:23]2[CH:32]=[CH:31][CH:30]=[C:29]([N+:33]([O-:35])=[O:34])[C:24]=2[C:25]([O:27][CH3:28])=[O:26])(=[O:21])=[O:22])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 33944N-(2-Aminoethyl)piperidineHCID 81531DiisopropylethylamineHCID 13670189Methyl 2-(chlorosulfonyl)-6-nitrobenzoate

생성물 1

HCID 20033758HCID 20033758, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 1-(2-aminoethyl)piperidine (0.23 g, 1.79 mmol) and N,N-diisopropylethylamine (0.23 g, 1.79 mmol) in tetrahydrofuran (5 ml) is added over 15 minutes to a stirred solution of methyl 2-chlorosulfonyl-6-nitrobenzoate (0.50 g, 1.79 mmol) in tetrahydrofuran (25 ml) cooled with an ice bath. The product is isolated following the procedure of Example 1 and converted to the hydrochloride salt with anhydrous ethanolic hydrogen chloride.

후처리

  1. temperaturecooled with an ice bath
  2. customThe product is isolated

출처 및 근거

ORD 기록
ord-79c3fb9ef8b34868bac35350431e7f93
출처 데이터셋
uspto-grants-1987_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04694020

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