4-Chlorobenzoyl chloride → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

HRID 2309236

반응식

[NH2:1][C@@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:1][CH:2]([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][CH:5]=2)[C:13]([OH:15])=[O:14])=[O:22])=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 85014-Chlorobenzoyl chloride

HCID 9060D-Tryptophan

생성물 1

HCID 27875262-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid수율 74.5%

실험 절차

By using 10 g of D-tryptophane and 9 g of 4-chlorobenzoyl chloride, and a method similar to that described in reference Example 6, recrystallized from methanol-water, there was obtained 12.5 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. Colorless needle-like crystals. Melting point: 100°-102° C. [α]D20 +51.5° (C=1, methanol)

후처리

customrecrystallized from methanol-water

출처 및 근거

ORD 기록: ord-5fbb4fe6c0ce401e867bd68064d97d00
출처 데이터셋: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04694017

연결된 노트

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