Hydrochloric Acid → 4-Acetyl-4-pentylheptanedinitrile

HRID 2309292노트

반응식

HRID 2309292 반응식
[CH3:1][C:2](=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-].[K+].CO.[C:14](#[N:17])[CH:15]=[CH2:16].Cl>C(O)(C)(C)C>[C:2]([C:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])([CH2:16][CH2:15][C:14]#[N:17])[CH2:16][CH2:15][C:14]#[N:17])(=[O:9])[CH3:1]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7855AcrylonitrileHCID 80932-OctanoneHCID 23689386Potassium hydroxide methanol

생성물 1

HCID 126597364-Acetyl-4-pentylheptanedinitrile

시약·촉매·용매 1

HCID 6386tert-Butanol용매2회

반응 조건

온도
5 °C

실험 절차

In a flask, 600 g of 2-octanone (CH3 (CH2)5COCH3), 500 g of tert-butanol ((CH3)3COH) and 30 g of a KOH/CH3OH solution were mixed and then stirred under ice-cooling. To the resulting solution was added dropwise a solution of 375 g of acrylonitrile (CH2 =CHCN) in 400 g of (CH3)3COH while maintaining the temperature at 5° C. or lower. After completion of the addition, the resulting solution was further stirred continuously for 1 hour, after which this reaction solution was made neutral by addition of dilute hydrochloric acid. The deposited salt was separated by filtration, and the residue was distilled under reduced pressure to obtain 3-acetyl-1,5-dicyano-3-pentylpentane.

후처리

  1. temperaturecooling
  2. additionAfter completion of the addition
  3. stirringthe resulting solution was further stirred continuously for 1 hour
  4. customThe deposited salt was separated by filtration
  5. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-00508129dfd84b6593cc333c62675c84
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04694098

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