Hydrochloric Acid → 2-Acetyl-4-methoxycyclohexanone

HRID 231219

반응식

HRID 231219 반응식
[C:1](OCC)(=[O:3])[CH3:2].[H-].[Na+].[CH3:9][O:10][CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.Cl>C1C=CC=CC=1.O.CO>[C:1]([CH:15]1[CH2:16][CH:11]([O:10][CH3:9])[CH2:12][CH2:13][C:14]1=[O:17])(=[O:3])[CH3:2]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 24758Sodium hydride2회HCID 5350284-Methoxycyclohexanone

생성물 1

HCID 136327242-Acetyl-4-methoxycyclohexanone수율 43.2%

시약·촉매·용매 3

HCID 241Benzene용매HCID 887Methanol용매HCID 962Water용매

실험 절차

To 2.5 g of ethyl acetate was added 1.12 g of 60% sodium hydride and, a solution of 1.78 g of 4-methoxycyclohexanone in benzene was added to the mixture. After reacting at 40° C. for 3 hours, methanol was added to decompose an excess of sodium hydride, which was poured into water. The mixture was neutralized with hydrochloric acid ahd extracted with ether to give 1.02 g of 2-acetyl-4-methoxycyclohexanone.

후처리

  1. extractionahd extracted with ether

출처 및 근거

ORD 기록
ord-be6ece670b8f49489d05b7e0c43e9ab9
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845228

연결된 노트

불러오는 중…