Hydrochloric Acid → Diethyl 2-(5-nitropyridin-2-yl)malonate

HRID 231633노트

반응식

HRID 231633 반응식
[OH-].[Na+].[C:3]([O:11][CH2:12][CH3:13])(=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][N:16]=1.Cl>CN(C)C=O.O>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[C:3]([O:11][CH2:12][CH3:13])=[O:10])=[N:16][CH:17]=1)([O-:23])=[O:22]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 14798Sodium HydroxideHCID 783082-Chloro-5-nitropyridine

생성물 1

HCID 2794558Diethyl 2-(5-nitropyridin-2-yl)malonate

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매2회

실험 절차

2.7 g (67.5 mmol) of powdered NaOH are introduced into 10.8 g (675 mmol) of diethyl malonate in 30 ml of dimethylformamide at room temperature, with cooling, a solution of 5 g (31 mmol) of 2-chloro-5-nitropyridine in dimethylformamide is then added dropwise and the mixture is stirred at room temperature until the reaction is complete. For working up, the mixture is poured onto 500 ml of water and acidified with concentrated HCl and the precipitate is filtered off with suction and rinsed with petroleum ether.

후처리

  1. temperaturewith cooling
  2. filtrationthe precipitate is filtered off with suction
  3. washrinsed with petroleum ether

출처 및 근거

ORD 기록
ord-fa369518d4ad4be091cbebb3c232b350
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847382

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