2-Amino-2-methyl-1-propanol → 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

HRID 23182

반응식

HRID 23182 반응식
C(O[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])C.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19]>C1(C)C=CC=CC=1>[OH:19][CH2:18][C:17]([NH:16][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])([CH3:21])[CH3:20]

참가 물질

4

반응물 2

HCID 118072-Amino-2-methyl-1-propanolHCID 90088Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate

생성물 1

HCID 111960052-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Method B): 5-Ethoxycarbonylphthalid (82 g, 0.4 mole) is added to a solution of 2-amino-2-methylpropan-1-ol (44.6 g. 0.5 mole) in toluene (100 ml). The mixture is heated to reflux temperature for 24 hours. Upon cooling the title compound is filtered off and recrystallised from hot toluene.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature for 24 hours

출처 및 근거

ORD 기록
ord-b1c7e6f305a2432c90684e7fd8d07359
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849749B2

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