[C:1]([CH2:3][CH2:4][NH:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])#[N:2].Cl[C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15](S(C)(=O)=O)[N:14]=1.C(N(C(C)C)CC)(C)C.[NH:33]1[CH:37]=[CH:36][N:35]=[CH:34]1>CS(C)=O>[C:1]([CH2:3][CH2:4][N:5]([C:13]1[CH:18]=[C:17]([CH3:19])[N:16]=[C:15]([N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)[N:14]=1)[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])#[N:2]
To N-cyanoethylglycine, ethyl ester (15.9 g, 102 mmol) (a compound of formula (Y2)) dissolved in DMSO (70 mL) was added 4-chloro-6-methyl-2-methylsulfonylpyrimidine (18.8 g, 91 mmol) (a compound of formula (Y1)) and diisopropylethylamine (18 mL, 100 mmol). After stirring for 16 hours, the reaction temperature was raised to 70° C. and imidazole (26.5 g, 0.39 mol) was added. After stirring for 1 day, the reaction was cooled to ambient temperature and added to ice water. The solid that formed was suction filtered and collected on paper to give 9.9 g of 2-[(2-cyanoethyl)[2-(1H-imidazol-1-yl)-6-methyl-4-pyrimidinyl]amino]acetic acid, ethyl ester (a compound of formula (Yc1)).
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