Hydrochloric Acid → N-(Prop-2-en-1-yl)heptan-1-amine
반응식
[CH2:1]([NH2:4])[CH:2]=[CH2:3].[CH:5](=O)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].C([BH3-])#N.[Na+].Cl>O.CO>[CH2:1]([NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH:2]=[CH2:3]참가 물질
7
실험 절차
To 100 mL of methanol is added 2-propenylamine (5.7 g, 0.1 mol), 11.4 g (0.1 mol) of heptaldehyde, and 12 g (0.2 mol) of sodium cyanoborohydride. The pH is adjusted to six with concentrated HCl. Monitor the reaction by thin-layer chromatography. Upon completion, add concentrated HCl until gas evolution ceases. Add 300 mL of H2O and extract once with 200 mL of ether. Add 1N NaOH to the aqueous solution until it is basic and extract twice with 200 mL of ether. Dry the organic phase over Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.
후처리
- customMonitor the reaction by thin-layer chromatography
- extractionextract once with 200 mL of ether
- additionAdd 1N NaOH to the aqueous solution until it
- extractionextract twice with 200 mL of ether
- dry with materialDry the organic phase over Na2SO4
- filtrationFilter off the drying agent
- customevaporate the solvent in vacuo
출처 및 근거
- ORD 기록
- ord-c1e36d85dfd74e0eac0b191df81269ad
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04851526
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