Hydrochloric Acid → 1,2-Diethyl-4-piperidinone

HRID 232274

반응식

HRID 232274 반응식
C[Si](C)(C)[O:3][C:4]([CH:6]=[CH2:7])=[CH2:5].[CH2:10]([NH:12][CH2:13][CH2:14][CH3:15])[CH3:11].B(F)(F)F.CCOCC.Cl>C(Cl)Cl>[CH2:10]([N:12]1[CH2:7][CH2:6][C:4](=[O:5])[CH2:3][CH:13]1[CH2:14][CH3:15])[CH3:11]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8000Boron trifluoride etherateHCID 883981-Propanamine, N-ethyl-HCID 5546572-(Trimethylsiloxy)-1,3-butadiene

생성물 1

HCID 200313151,2-Diethyl-4-piperidinone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.

후처리

  1. customMonitor the reaction by thinlayer chromatography
  2. customSeparate the aqueous layer
  3. extractionExtract twice with 100 mL ether
  4. dry with materialdry over Na2SO4
  5. filtrationFilter the drying agent
  6. customevaporated the solvent in vacuo

출처 및 근거

ORD 기록
ord-dc7eb3e1a8054954978500e3c6bd556b
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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